SYNTHESIS OF 5-BENZIMIDAZOLYLBENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY

Authors

  • Fatma AbdAleem A.ElHag Taibah University College of Applied Science, Applied Chemistry Department, Al-Madinah Al-Munawara, Saudi Arabia
  • Reem A.K. ElHarbi Taibah University College of Applied Science, Applied Chemistry Department, Al-Madinah Al-Munawara, Saudi Arabia
  • Fatma M. Edress Taibah University College of Applied Science, Applied Chemistry Department, Al-Madinah Al-Munawara, Saudi Arabia
  • Hoda I. El Diwani Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo, Egypt

DOI:

https://doi.org/10.19044/esj.2013.v9n21p%25p

Abstract

The benzimidazole starting material 5-(1H-benzo[d]imidazol-2-yl)-4,7-dimethoxybenzofuran- 6-ol (2)was synthesized. The Mannich bases 3a-k were formed using formaldehyde and primary or secondary amines.(2) was subjected to Mannich reaction using 1,4-phenylenediamine or piperazine to lead to the 1,4-disubstituted benzenes 4a or 1,4-disubstituted piperazines 4b. The compounds were screen for their antimicrobial activities

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Published

2013-07-12

How to Cite

A.ElHag, F. A., ElHarbi, R. A., Edress, F. M., & El Diwani, H. I. (2013). SYNTHESIS OF 5-BENZIMIDAZOLYLBENZOFURAN DERIVATIVES OF EXPECTED BIOLOGICAL ACTIVITY. European Scientific Journal, ESJ, 9(21). https://doi.org/10.19044/esj.2013.v9n21p%p

Issue

ESJ June 2013 /special/ edition No.3

Section

Articles

License

This work is licensed under a Creative Commons Attribution 4.0 International License.