TOTAL ANTIOXIDANT CAPACITY AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALKALOID EXTRACT FROM AERIAL PART OF ANETHUM GRAVEOLENS L. PLANT

Authors

  • Adnan J.M. Al–Fartosy Chemistry Department, College of Science, Basra University, Iraq
  • Sameerah Ahmed Zearah Chemistry Department, College of Science, Basra University, Iraq
  • Nawras A. Alwan Physiological and Chemistry Department, College of Veterinary Medicine, Basra University, Iraq

DOI:

https://doi.org/10.19044/esj.2013.v9n33p%25p

Abstract

Compounds of pharmacological interest (alkaloids) were extracted and the results revealed that the extract consist of three alkaloid compounds (A, B & C). Compound (A) has been isolated from Anethum graveolens L. aerial parts by column chromatography using C6H6 : Ethanol (9:1) solvent as eluent. It was found that simultaneous administration of alkaloid compound A (500 mg/kg/day) and cholesterol for 4 weeks, significantly (P<0.01) prevented the rise in serum TC, TG, LDL-cholesterol, VLDL-cholesterol, atherogenic index and significantly (P<0.01) increased TAC and HDL-cholesterol as compared to cholesterol fed control rabbits. Thus, the results indicate antioxidant and hypolipidemic effect of alkaloid compound A of Anethum graveolens L. aerial parts.

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Published

2013-11-30

How to Cite

Al–Fartosy, A. J., Zearah, S. A., & Alwan, N. A. (2013). TOTAL ANTIOXIDANT CAPACITY AND ANTIHYPERLIPIDEMIC ACTIVITY OF ALKALOID EXTRACT FROM AERIAL PART OF ANETHUM GRAVEOLENS L. PLANT. European Scientific Journal, ESJ, 9(33). https://doi.org/10.19044/esj.2013.v9n33p%p

Issue

Vol. 9 No. 33 (2013): ESJ November Edition

Section

Articles

License

This work is licensed under a Creative Commons Attribution 4.0 International License.