TYPES OF AUTOIMMUNE POLYENDOCRINOPATIES IN CHILDREN WITH DIABETES MELLITUS TYPE 1 AND THYROID DISEASE

Abstract

Background&Aims: If are associated multiple autoimmune
endocrine diseases, the term is polyglandular autoimmune syndrome (PAS).
The main autoimmune polyendocrinopaties encountered are: PAS I (chronic
mucocutaneous candidiasis, chronic autoimmune hypoparathyroidism, and
autoimmune Addison disease), PAS II (autoimmune Addison's disease,
autoimmune thyroid disease and/or type 1 diabetes) and PAS III
(autoimmune thyroid disease + other autoimmune diseases). The purpose of
this study is to determine the types of PAS in a group of children with
thyroid diseases and diabetes mellitus (DM) type 1.
Methods: The studied group was of 83 children with DM type 1 (71 girls
and 12 boys), aged between 7 and 17 years. The methods of investigation
were represented by clinical, imaging, biochemical, hormonal and
immunological parameters.
Results: The prevalence of PAS in the study group was: type I – 0%, type II
- 6.02 % (80% girls and 20 % boys, p = 0.057, X2 = 3.6) and type III - 59.03
% (85.71% girls and 14.29% boys, p < 0.001, X2 = 50). We don’t find
significant differences between boys and girls in the case of PAS type II, but
in type III prevailed girls, and the type was III a.
Conclusions: The most frequent PAS was type III, subtype III a, follow by
type II. Because Addison's disease was asymptomatic, identifying through
the presence of specified antibodies, if we have a children with two or more
autoimmune disease, we must investigate him for another possible
autoimmune disease.