EFFET TOPIQUE DE L’EXTRAIT HYDROETHANOLIQUE DE L’ACACIA NILOTICA SUR LA CICATRISATION CUTANEE DES BRULURES DE SECOND DEGRE

Abstract

The purposeof this study was to evaluate experimentally Acacia nilotica burn wound healing effect.Fourgroups of ratswere formed andeach batchconsisted oftwelverats. Burn wounds were assessed by planimetry and histological parameters of healing.Twelve days after burn wound induction, wound contraction in the uninfected groups was 19,9% for topical application of A. nilotica 2,5% gel, and 22% for a 5% gel versus 26,1% with the reference drug used (Brulex ®) against 15.5% in uninfected controls. In the infected group, wound contraction was generally lower. Histological examination showed granulated tissue developing over the wounds treated with the extract of A. nilotica at 2,5% and 5% where the proliferation of fibroblasts and neo-blood vessels was very marked. The determination of hydroxyproline in the 12th day was significant in the groups treated with the extract of A. nilotica 2,5% and 5%. Acacianilotica significantly accelerates the healing ofburn wounds.